Cat.No. ABS 033-04
ABS 033-04 binds the free N-terminus of GLP-1(7-37) and GLP-1(7-36)amide and shows <0.2% cross-reactivity with GLP-1(1-37), GLP-1(9-36)amide, glucagon, human GIP and exendin-4. Cross-reacts approximately 1% with human GLP-2.
Free N-terminus of GLP-1(7-37) and GLP-1(7-36)amide.
Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.
Glucagon-like peptide 1(7-36)amide (GLP-1(7-36)amide) is the principal active form of GLP-1, the other being GLP-1(7-37). GLP-1 is a peptide hormone of the glucagon family, produced by the L cells of the intestinal mucosa from the same prohormone as glucagon. The active forms are potent stimulators of glucose-dependent insulin secretion. The sequence of GLP-1 is fully conserved in all mammalian species examined so far.
ABS 033-04 binds free GLP-1(7-37) and free GLP-1(7-36)amide. Not recommended for use in sandwich ELISA. (1)
ABS 033-04 can be used in IHC.
|Endocrine alpha cells from diabetic mice stained with ABS 033-04 (1:500). Courtesy of Dr. Annette Plesner, University of British Columbia|
1. Murphy RE, Kinhikar AG, Shields MJ, Rosario JD, Preston R, Levin N, Ward GH (2010) Combined use of immunoassay and two-dimensional liquid chromatography mass spectrometry for the detection and identification of metabolites from biotherapeutic pharmacokinetic samples. Journal of Pharmaceutical and Biomedical Analysis 53:221-227.