Cat.No. HYB 116-03B
Mouse monoclonal antibody, biotinylated
HYB 116-03 reacts with influenza B virus nucleoprotein as demonstrated by immunoblotting after SDS-PAGE. HYB 116-03 does not cross-react with influenza A virus.
Unpurified influenza B virus (B/Lee/40) for primary intranasal immunization, boosted intravenously with purified influenza B virus disrupted with Triton X-100 for 40 min at 37°C.
Epitope differs from HYB 116-01 and HYB 116-02 as determined by inhibition ELISA.
100 µL, 1 mg/mL +/- 15%. See Certificate of Analysis for details.
Influenza viruses are common and highly infectious human pathogens. They are constantly mutating to modify their antigenicity and avoid elimination by immunity to previous generations of virus. The nucleoprotein of influenza B virus is a basic, phosphorylated multimeric protein consisting of 560 aa subunits that encapsidate the viral RNA genome to form a ribonucleoprotein particle.
1. Glikmann G, Chen S-N, Mordhorst CH, Koch C (1995) Monoclonal antibodies for the rapid diagnosis of influenza-B virus infections by ELISA: production and characterization. Clin Diagn Virol 4:27-42.