Anti-von Willebrand factor (human, vWf)

Cat.No. HYB 060-01

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Cat. No.
HYB 060-01
Product name
Anti-von Willebrand factor (human, vWf)
Description

Mouse monoclonal antibody

Specificity

HYB 060-01 is specific for human vWf from human serum or plasma

Immunogen

Factor VIII complex isolated from human plasma

Application
Species reactivity (positive)
Human
Species reactivity (negative)
Not determined
Subclass

IgG1/k

Gene ID
7450
Clone number
5E7
Content

Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.

Purification
Protein-A purified
Form
Liquid
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target

Von Willebrand factor (vWf) is a series of self-aggregated structures, all derived from common glycoprotein subunits, synthesized in endothelial cells and megakaryocytes. The molecular mass of the monomeric vWf unit is 225 kDa. vWf  binds to circulating factor VIIIc (antihemophilic factor), hereby stabilizing the latter thus being an important factor in the normal primary haemostasis.

Application 1

ELISA

HYB 060-01 reacts strongly with vWf. A strong reaction is seen in ELISA with vWf directly coated onto the microtiterplate, and also when used in sandwich ELISA in combination with a polyclonal antibody against the antigen (e.g. DAKO A082).

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