Anti-Vitronectin (bovine, horse, rabbit)

Cat.No. CSI 004-18

Cat. No.
CSI 004-18
Product name
Anti-Vitronectin (bovine, horse, rabbit)
Description
Mouse monoclonal antibody
Specificity
CSI 004-18 is highly specific for vitronectin. There is no evidence for cross-reactivity with other connective tissue proteins (fibronectin, elastin, collagen, laminin). The antibody inhibits integrin-mediated cell adhesion to bovine vitronectin. It can be used to probe vitronectin conformation.
Immunogen
Lysed bovine corneal endothelial cells and extracellular matrix
Species reactivity (positive)
Bovine, horse, rabbit
Species reactivity (negative)
Human, sheep
Subclass
IgG1/k
Gene ID
507525, 100009128, 100059034
Clone number
A18
Epitope
Not determined
Content
Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.
Purification
Protein-A purified
Form
Liquid
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target
Vitronectin is a plasma glycoprotein that circulates in the blood. Vitronectin is circulating as a mixture of both 75 kDa and 65 kDa forms. Vitronectin is a major cell adhesive glycoprotein and is a common component of extracellular matrix and plasma. It competes effectively with other plasma proteins and is often involved in cell attachment, regulation of blood coagulation and immune responses. It has similar tissue distribution to fibronectin and also its integrin receptor recognises fibronectin
Application 1
ELISA
CSI 004-18 reacts weakly in ELISA with vitronectin coated directly onto the microtiter plate. 
Application 2
IHC
CSI 004-18 is suitable in ELISA and immunostaining of frozen PLP-fixed sections of bovine tissues.