Cat.No. ABS 006-01
Mouse monoclonal antibody
ABS 006-01 is specific for native human PAPP-A
Purified human PAPP-A
The epitope of ABS 006-01 is different from BTE 004-09 and ABS 001-24. The epitope is located on the PAPP-A subunit of the heterotetramer.
Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.
Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down’s syndrome (trisomy 21).
In sandwich ELISA with a polyclonal antibody in coat, ABS 006-01 only reacts poorly with PAPP-A in third trimester serum.
ABS 006-01 only detects unreduced PAPP-A in Western blotting.
|Paraffin-embedded human placenta tissue immunostained with ABS 006-01 (www.proteinatlas.org)|
|Immunohistochemical staining of a formalin-fixed, paraffin-embedded placental tissue with ABS 006-01|