Cat.No. ABS 061-09
Mouse monoclonal antibody
ABS 061-09 binds human glucagon. Cross-reacts less than 5% with oxyntomodulin.
Synthetic C-terminal fragment of glucagon coupled to carrier
The epitope lies within the C-terminal region of glucagon.
Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.
Glucagon is a peptide hormone of 29 amino-acid residues produced by the alpha cells of the pancreatic islets. Its effect is to raise blood sugar as a stress hormone and counter-regulatory hormone for insulin. It is produced by cell-type-specific processing of proglucagon, which in the alpha cells is split to form glicentin-related pancreatic polypeptide, glucagon and major proglucagon fragment, while the same precursor is split to form glicentin, oxyntomodulin (C-terminally extended glucagon-37), GLP-1 and GLP-2 in the L cells of the intestinal mucosa.
|The calibration curve of a sandwich assay for Glucagon using ABS 061-09 as the capture antibody and ABS 058-08B as the biotinylated detection antibody.|
ABS 061-09 has been used in IHC.
|Formalin fixed paraffin-embedded human pancreas tissue stained with ABS 061-09. Alpha cells of the Langerhans islet were stained strongly. Dilution: 1:8000|
ABS 061-09 has been used in IF.
|IF staining in human pancreas tissue stained with ABS 061-09. Signal is strong in alpha cells. Dilution: 1:4000.|