Cat.No. CAM 011-05
Mouse monoclonal antibody
CAM 011-05 binds the heavy chain of human factor XII, including factor XII derivatives such as α-factor XIIa and α-factor XIIa C1-inhibitor complexes.
Affinity purified human factor XII.
Differs from CAM 011-37.
Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.
Factor XII is a component in the coagulation cascade. It is a plasma glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII to a-factor XIIa, which in turn activates factor XI to factor XIa.
CAM 011-05 was used in ELISA. Biotinylated CAM 011-05 (1 μg/mL) was used as a detection antibody when used in combination with CAM 011-37 as a capture antibody (1.6 μg/mL) to measure Total α-factor XIIa and α-factor XIIa C1-inhibitor complexes) (1).
|The calibration curve of a sandwich assay for Anti-Factor XII using CAM 011-37 as the capture antibody and CAM 011-05B as the biotinylated detection antibody.|
CAM 011-05 was used in western blot to detect factor XII, α-factor XIIa C1-inh complexes and α-factor XIIa.