Anti-Complement component C1 inhibitor (human, C1INH)

Cat.No. HYB 288-05

Cat. No.
HYB 288-05
Product name
Anti-Complement component C1 inhibitor (human, C1INH)
Description

Mouse monoclonal antibody

Specificity

HYB 288-05 is specific for human C1INH

Immunogen

C1-inhibitor (C1INH) isolated from human plasma

Application
Species reactivity (positive)
Human
Species reactivity (negative)
Not determined
Subclass

IgG1/k

Gene ID
710
Clone number
8 F3
Epitope

Epitope specificity differs from that of HYB 288-02

Content

Available in 200 µL and 1 mL size.1 mg/mL +/- 15%. See Certificate of Analysis for details.

Purification
Protein-A purified
Form
Liquid
Solvent
0.01 M phosphate buffer, pH 7.4, containing 0.5 M NaCl and 15 mM sodium azide
Storage
4-8ºC without exposure to light. No precautions necessary during handling.
Target

C1-inhibitor (C1INH) functions as a regulator of the activation of the classical complement pathway and of the contact activation system of kinin generation and coagulation. Its primary biologically relevant target proteinases are C1r, C1s, coagulation factors XIa and XIIa, and plasma kallikrein. C1-inhibitor consists of one polypeptide chain and has a molecular mass of 104 kDa. Serum concentration has been determined to 180 µg/ml.

Application 1

ELISA
HYB 288-05 reacts strongly with C1-INH. A strong reaction is seen with human serum/plasma when tested in sandwich ELISA in combination with a polyclonal antibody against C1-INH, and in ELISA with C1-INH coated directly onto the microtiter well.

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